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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).patients with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetickidney disease (NADKD) or nonalbuminuric diabetic nephropathy.Epidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigatedendogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidneydisease (CKD) to predict putative microRNA (miRNA) in CKD–mineral bone disorder (CKD–MBD

Keywords： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholic fatty liver diseaseDiabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetickidney disease (DKD).

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract:

Kidney damage is common in patients with diabetes mellitus (DM).However, whether the type of kidney damage can be reliably diagnosed using clinical data alone remainsPredictive factors for diabetic nephropathy (DN) outcomes are also poorly understood.Hematuria (48.6%) failed to specify either DN or nondiabetic renal disease.Diabetic retinopathy (78.4%) was a crucial complication in patients with DN.

Keywords： diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Frontiers of Medicine doi: 10.1007/s11684-023-1019-5

Abstract: Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) riskincluded 104 538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic

Keywords： sleep     physical activity     chronic kidney disease     isotemporal substitution     behavioral pattern    

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Hyperglycemic memory in diabetic cardiomyopathy

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 25-38 doi: 10.1007/s11684-021-0881-2

Abstract: Cardiovascular diseases account for approximately 80% of deaths among individuals with diabetes mellitus, with diabeticcardiomyopathy as the major diabetic cardiovascular complication.herein the current advances that have been achieved in research on the underlying mechanisms of HGM in diabetic

Keywords： diabetes     diabetic cardiomyopathy     hyperglycemic memory    

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Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 80-85 doi: 10.1007/s11684-011-0115-0

Abstract: This study reports our experience in kidney transplantation in highly sensitized patients.desensitization using PP/IVIG with or without rituximab increases the likelihood of successful live-donor kidney

Keywords： Kidney transplantation     desensitization    

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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidneyof diabetic mice.Imaging results showed that the pH value in kidney of diabetic mice was lower than that of the normalmice, while the pH value in liver of diabetic mice was almost the same as that of the normal mice.

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 389-393 doi: 10.1007/s11684-014-0362-y

Abstract:

Studies conducted by our group on the mechanism of “kidney governing bones” theory in” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and notAlthough both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney;kidney governing bones” remains complicated and unresolved.

Keywords： kidney governing bones     kidney deficiency     marrow     osteoporosis     neuroendocrine-immune network     osteoclast    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainHospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by KidneyDisease Improving Global Outcomes.Multivariate logistic regression analysis revealed that high AKI stage, age greater than 80 years, neoplastic diseaseIncreased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factors

Keywords： acute kidney injury     risk factors     prognosis    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract:

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitusDN has become the leading cause of end-stage renal disease.However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidneydisease

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: corresponding tumors is decreased while others remain as valuable as they are in patients with normal kidneyIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseasedecreased while serum AFP, CA, CA, PSA and fPSA were as valuable as they were in patients with normal kidney

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 741-746 doi: 10.1007/s11684-017-0579-7

Abstract: Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD).

Keywords： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

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Title Author Date Type Operation

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Journal Article

Hyperglycemic memory in diabetic cardiomyopathy

Journal Article

Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Journal Article

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidneydisease

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Journal Article